This practice guide outlines Wirral’s innovative multi-agency response to rising ketamine use among young people, led by the Youth Justice Service and Harm Outside the Home Service. In response to increasing referrals and arrests linked to ketamine, the Wirral Drugs Partnership launched a coordinated initiative focused on education, prevention, and early intervention. Key actions included the development of co-produced harm reduction materials, widespread awareness sessions in schools and colleges, professional training for over 600 practitioners, and the creation of screening tools and multimedia resources. The initiative has significantly increased awareness, early referrals, and access to support services, reaching over 15,000 young people across the borough.